Synthesis and antioxidant evaluation of (S, S)-and (R, R)-secoisolariciresinol diglucosides (SDGs)

OP Mishra, N Simmons, S Tyagi, R Pietrofesa… - Bioorganic & medicinal …, 2013 - Elsevier
… Since such a compound may have diverse antioxidant properties, we chose to evaluate
our … we proceeded to evaluate the reducing power of synthesized (S,S)-SDG-1 and (R,R)-SDG-2 …

Secoisolariciresinol diglucoside-a phytoestrogen nutraceutical of flaxseed: synthesis and evaluation of antioxidant potency

SS Moree, J Rajesha - Free Radicals and Antioxidants, 2011 - Elsevier
… These health benefits of SDG may be partially attributed to its antioxidant properties. … the
present study, SDG was synthesized for the first time and screened for its antioxidant properties. …

Investigation of in vitro and in vivo antioxidant potential of secoisolariciresinol diglucoside

SS Moree, J Rajesha - Molecular and cellular biochemistry, 2013 - Springer
Secoisolariciresinol diglucoside (SDG) is the abundant major … SDG could be a potent
antioxidant [9]. It is also reported that … Chemical synthesis of SDG was accomplished through a …

Novel Synthetic (S,S) and (R,R)-Secoisolariciresinol Diglucosides (SDGs) Protect Naked Plasmid and Genomic DNA From Gamma Radiation Damage

OP Mishra, R Pietrofesa… - Radiation …, 2014 - meridian.allenpress.com
… In view of these needs, we have synthesized enantiomers of secoisolariciresinol diglucoside
(SDG), which is the … ,R), which we have shown to possess potent antioxidant properties. …

Antioxidant activities of the flaxseed lignan secoisolariciresinol diglucoside, its aglycone secoisolariciresinol and the mammalian lignans enterodiol and enterolactone …

C Hu, YV Yuan, DD Kitts - Food and chemical toxicology, 2007 - Elsevier
… a paucity of data evaluating the antioxidant activity of the flaxseed lignan SDG, its aglycone
… study was to evaluate the antioxidant efficacy of the flaxseed lignan SDG, its aglycone SECO…

[HTML][HTML] Potential protective properties of flax lignan secoisolariciresinol diglucoside

…, Z Mushtaq, M Nadeem, S Hussain - Nutrition …, 2015 - nutritionj.biomedcentral.com
… precursor such as secoisolariciresinol diglucoside (SDG). This … SDG is coherent with LuPLR
gene expression and synthesis … enriched with SDG compounds exhibit antioxidant activity …

Antidiabetic effect of secoisolariciresinol diglucoside in streptozotocin-induced diabetic rats

SS Moree, GB Kavishankar, J Rajesha - Phytomedicine, 2013 - Elsevier
… in the level of antioxidants. The aim of this study was to determine the … activity of synthetic
Secoisolariciresinol diglucoside (SDG) in … SDG was synthesized via a novel five-step synthesis

A review of flaxseed lignan and the extraction and refinement of secoisolariciresinol diglucoside

Y Hu, TJ Tse, YY Shim, SK Purdy, YJ Kim… - Critical Reviews in …, 2022 - Taylor & Francis
… of the lignan secoisolariciresinol diglucoside (SDG) are not well … SDG is an antioxidant
and a metabolic precursor for … The synthesis of SDG (Figure 4) begins with an enzyme-catalyzed …

Synthetic Secoisolariciresinol Diglucoside Attenuates Established Pain, Oxidative Stress and Neuroinflammation in a Rodent Model of Painful Radiculopathy

S Kartha, CL Weisshaar, RA Pietrofesa… - Antioxidants, 2020 - mdpi.com
secoisolariciresinol diglucosides (S,S)-SDG (the major isomer in whole grain flaxseed) and
(R,R)-SDG … flaxseed) were synthesized from vanillin via secoisolariciresinol and glucosyl …

The flaxseed-derived lignan phenolic secoisolariciresinol diglucoside (SDG) protects non-malignant lung cells from radiation damage

A Velalopoulou, S Tyagi, RA Pietrofesa… - International journal of …, 2015 - mdpi.com
… that an SDG-rich diet (FLC) upregulates the antioxidant enzymes… of SDG in free-radical
scavenging and antioxidant defense … synthesize SDG (LGM2605) to enable preclinical evaluation